RK-33 - DDX3 inhibitor. CAS# 1070773-09-9 Catalog No.:M6511-2 6-difluorobenzenesulfonamide

6-difluorobenzenesulfonamide

1 Inhibitors of NEP have been shown to increase plasma levels of endogenous atrial natriuretic peptides and

and reduced brain atrophy

InChi: InChI=1S/C20H23F3N4O3S/c21-20(22

RK-33 - DDX3 inhibitor. CAS# 1070773-09-9 Catalog No.:M6511-2 6-difluorobenzenesulfonamideDDX3 inhibitor, CAS No. 1070773 09 9, RK 33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK 33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3 overexpressing cells. Overall, inhibition of DDX3 by RK 33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. RK 33 radiosensitizes prostate cancer cells by blocking the RNA helicase