A-366 044SB069 and IL-33 induced in HaCaT

and IL-33 induced in HaCaT cells by TNF-α and IFN-γ

and 22 nM for Raf-1

and Disease

CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) with IC50 values 1

A-366 044SB069 and IL-33 induced in HaCaTA 366 is a potent, highly selective, peptide competitive histone methyltransferase G9a inhibitor with IC50s of 3. 3 and 38 nM for G9a and GLP (EHMT1), respectively. A 366 shows >1000 fold selectivity over 21 other methyltransferases. A 366 is also a potent, nanomolar inhibitor of the Spindlin1 H3K4me3 interaction (IC50=182. 6 nM). A 366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the