GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 Harmine was dosed by intraperitoneal

Harmine was dosed by intraperitoneal injection at 10 mg/kg in mouse partial pancreatectomy model (PPX)

112(6):1839-44

638156-11-3

MLL have been observed in acute myeloid leukemia

GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 Harmine was dosed by intraperitonealGNF 7, CAS No. 839706 07 9, is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF 7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples. Product information CAS Number: 839706 07 9 Molecular Weight: 547. 53