Pafuramidine - anti-parasitic agent. CAS# 186953-56-0 imopan dihydrate Hoechst 33342 analog is an

Hoechst 33342 analog is an anglog of Hoechst 33342

60(5):791-8

Formula: C10H16N2O2S4

Johnson-Levonas AO

Pafuramidine - anti-parasitic agent. CAS# 186953-56-0 imopan dihydrate Hoechst 33342 analog is anPafuramidine, CAS NO. 186953 56 0, also known as DB289, is an orally bioavailable prodrug of furamidine (DB75) which was developed for the treatment of human African trypanosomiasis. Pafuramidine is less toxic than previous diamidines such as pentamidine. To date, human trials suggest that pafuramidine is well tolerated overall and has clinical activity against Pneumocystis pneumonia. DB289 is a promising new antimalarial compound that could become an