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112(6):1839-44
Bioanalysis
Formula: C18H24N6O
selective and cell permeable PARP-3 inhibitor with IC50 of 0
Midostaurin - CAS# 120685-11-2 60268 112(6):1839-44Midostaurin, CAS No. 120685 11 2, also known as PKC 412, PKC 412A and CGP 41251; is a synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c kit, platelet derived growth factor receptor (PDGFR) and FMS like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the
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