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The SMARC family A (SMARCA) members SMARCA2 (also known as BRM) and SMARCA4 (also known as BRG1) are helicases that contain structurally-related bromodomains for binding acetylated lysine residues on target proteins
Smiles: CN(C)CC1C(=CC(=CC=1OC)C1=CN(C)C(=O)C2=CN=CC=C12)OC
Chemical Name: 4-((4-((((1R
32)29(17(18(26)30)7-8-20(23
Carfilzomib - Proteasome Inhibitor. CAS# 868540-17-4 size:10 mg solid The SMARC family A (SMARCA)Carfilzomib, CAS No. 868540 17 4, is a selective, irreversible proteasome inhibitor (over 80% inhibition at doses of 10 nM and above). In models of multiple myeloma, Carfilzomib potently bound and specifically inhibited the chymotrypsin like proteasome and immunoproteasome activities, resulting in accumulation of ubiquitinated substrates. It induced a dose and time dependent inhibition of proliferation, ultimately leading to apoptosis. It also
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