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K-7174 Size:Solid 2 mg and selective acid pump antagonist

SKU: 1508583741

4.6
USD90.00 USD121.00

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Description

and selective acid pump antagonist with pIC50 of about of 6

Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad

Formula: C29H27F3N6O

Ser33 of RPA32

K-7174 Size:Solid 2 mg and selective acid pump antagonistK 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product

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