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FLI-06 - Notch Pathway Modulator. CAS# 313967-18-9 Catalog No.:M60149-10S 1 mg/kg results in efficacy

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Description

1 mg/kg results in efficacy comparable to that of naproxen at 10 mg/kg in a rat model of inflammatory pain

Wojnooski K

GJ-103 sodium

Alloatti G

FLI-06 - Notch Pathway Modulator. CAS# 313967-18-9 Catalog No.:M60149-10S 1 mg/kg results in efficacyFLI 06, CAS No. 313967 18 9, is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2. 3 M), identified by using automated microscopy to monitor the trafficking and processing of a ligand independent Notch GFP fusion reporter. FLI 06 can induce accumulation of the reporter at the plasma membrane by interfering with transport in the secretory pathway. It can also disrupt the Golgi apparatus in

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