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BAY-2416964 - CAS# 2242464-44-2 Catalog No.:M7082-2 Smiles: O=C(NCCCN1C=NC=C1)C1C=C(ON=1)C1=CC=CO1

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Description

Smiles: O=C(NCCCN1C=NC=C1)C1C=C(ON=1)C1=CC=CO1

is a potent Rho-kinase inhibitor and vasodilator

2ClH/c17-19(18

Mitchell JB

BAY-2416964 - CAS# 2242464-44-2 Catalog No.:M7082-2 Smiles: O=C(NCCCN1C=NC=C1)C1C=C(ON=1)C1=CC=CO1BAY 2416964, CAS No. 2242464 44 2, is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY2416964 specifically binds to AhR, inhibits AhR activation, and prevents AhR mediated signaling. Abrogation of AhR activation prevents the activation of immune tolerant dendritic cells (DCs) and regulatory T cells (Tregs) in the tumor microenvironment (TME). This may

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