![Ruxolitinib sulfate - CAS# 1092939-16-6 alog 2 Chemical Name: 1-({4-[2-(azepan-1-yl)ethoxy]phenyl}methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M10836_1621562552.gif?v=1742885855)
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Chemical Name: 1-({4-[2-(azepan-1-yl)ethoxy]phenyl}methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
Autotaxin's role in producing LPA in plasma and at the site of inflammation was tested in a rat air pouch model
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42(5):1822-1836
Ruxolitinib sulfate - CAS# 1092939-16-6 alog 2 Chemical Name: 1-({4-[2-(azepan-1-yl)ethoxy]phenyl}methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-olRuxolitinib sulfate is the first potent, selective JAK1 2 inhibitor to enter the clinic with IC50s of 3. 3 nM 2. 8 nM, and has > 130 fold selectivity for JAK1 2 versus JAK3. Ruxolitinib potently and selectively inhibits JAK2V617F mediated signaling and proliferation, markedly increases apoptosis in a dose dependent manner, and at 64 nM results in a doubling of cells with depolarized mitochondria in Ba F3 cells. Ruxolitinib demonstrates remarkable
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