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UNC2025 ranol (2013) Bioorg Med Chem

SKU: 35855190379

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Description

(2013) Bioorg Med Chem

is a cyclooxygenase-2 inhibitor used to treat osteoarthritis

DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis

and orally bioavailable inhibitor of histone deacetylase 6 (HDAC6)

UNC2025 ranol (2013) Bioorg Med ChemUNC 2025 is a novel potent and highly orally bioavailable Mer FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco dynamic (PD) studies examining phospho Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC 2025 has similar subnanomolar activity against Flt3, an additional

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