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Smiles: N[C@@H](CCCCN)C(O)=O
blocks Wnt-induced LRP6 phosphorylation
Degradation Inducing Moiety A
35)12-38)45-25-9-23(39-13-30(36
BAN ORL 24 dihydrochloride Size:Contact [email protected] for quotation Smiles: N[C@@H](CCCCN)C(O)=OBAN ORL 24 is a potent and selective NOP receptor antagonist. (IC50 values are 0. 27, 2500, 6700 and > 10000 nM for NOP, , and receptors respectively). IC50 value: 0. 27 nM Target: NOP receptor BAN ORL 24 inhibits nociceptin induced stimulation of [35S] GTPS binding and Ca2+ mobilization in CHO cells in vitro. BAN ORL 24 antagonizes NOP agonist induced reduction in locomotor activity in vivo. Brain penetrant. Product information CAS Number: 1401463 54
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