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Formula: C16H22O3
PubMed PMID: 24598368
as of July 2008
21(11):1463-75
CYT387 mesylate - CAS# 1056636-07-7 Catalog No.:M10494-2 Formula: C16H22O3Momelotinib Mesylate (CYT387 Mesylate) is an ATP competitive inhibitor of JAK1 JAK2 with IC50 of 11 nM 18 nM, appr 10 fold selectivity versus JAK3. Momelotinib inhibits the proliferation of parental Ba F3 cells (Ba F3 wt) stimulated by IL 3 with IC50 of 1400 nM. Furthermore, Momelotinib also causes the inhibition of cell proliferation in cell lines constitutively activated by JAK2 or MPL signaling, including Ba F3 MPLW515L cells, CHRF 288 11 cells and
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