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InChi: InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H
5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4
is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2
Italiano K
TX1-85-1 cium) InChi: InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11HTX1 85 1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1 85 1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP binding site of Her3. TX1 85 1 induces partial degradation of Her3 protein and attenuates Her3 dependent signaling. Product information CAS Number: 1603845 32 4 Molecular Weight: 580. 68 Formula: C32H36N8O3 Chemical Name: N (5 {1 [4 (4 acetylpiperazin 1 yl)cyclohexyl] 4
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