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The p110α-specific inhibitor A66 reduced phosphorylation of Akt on T308 by all p85 mutants
Smiles: CN(C)CCN(C)C1=CC(OC)=C(C=C1NC(=O)C=C)NC1=NC(=CC=N1)C1=CNC2=CC=CC=C12
Christoffersson E
PubMed PMID: 10762053
PROTAC BET degrader-3 imonin The p110α-specific inhibitor A66 reducedPROTAC BET Degrader 3 is a potent BET degrader based on PROTAC. Product information Molecular Weight: 1045. 22 Formula: C53H64N12O9S Chemical Name: (2S, 4R) 1 [(2S) 2 (2 {2 [2 ({4 [(3 cyclopropyl 1 ethyl 1H pyrazol 5 yl)amino] 7 (3, 5 dimethyl 1, 2 oxazol 4 yl) 6 methoxy 9H pyrimido[4, 5 b]indol 2 yl}formamido)ethoxy]ethoxy}acetamido) 3, 3 dimethylbutanoyl] 4 hydroxy N {[4 (4 methyl 1, 3 thiazol 5 yl)phenyl]methyl}pyrrolidine 2 carboxamide Smiles:
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