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also known as ONO 1206 and OP1206
Chemical Name: 7-oxo-7H-benzo[de]benzo[4
HIF pathway is the most significant pathway for cellular response to hypoxia
InChiKey: WAOODRHZYQRSDS-JBVYASIDSA-N
AP14145 hydrochloride Size:Contact [email protected] for quotation also known as ONO 1206AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1. 1 M for KCa2. 2 (SK2) and KCa2. 3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant resistant porcine model of atrial fibrillation (AF). Product
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