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McMurray JJV
(2013) Nat Chem Biol 9(4):271-6
Canertinib has been reported as a substrate for OATP1B3
67(19):9472-81
BO-264 - CAS# 2408648-20-2 Catalog No.:M7012-2 McMurray JJVBO 264, CAS No. 2408648 20 2, is a highly potent and orally active transforming acidic coiled coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1. 5 nM. BO 264 demonstrated superior anti proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC) dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against
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