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PMID: 31857844
39(12):858-80
20263-07-4
Yamashita Y
Elesclomol AY-600 PMID: 31857844Elesclomol, also known as STA 4783, is a HSP 90 Inhibitor, and is a small molecule bis(thio hydrazide amide) with oxidative stress induction, pro apoptotic, and potential antineoplastic activities. Elesclomol induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have elevated levels of ROS compared to normal cells, the increase in oxidative
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