![Oclacitinib - CAS# 1208319-26-9 Catalog No.:M9848-2 Smiles: CN1C(=O)C2=CN=C(C3CCOCC3)N2N=C1OC[C@@H]1CC[C@H](CC1)C(F)(F)F](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M9848_1621560901.gif?v=1742823394)
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Smiles: CN1C(=O)C2=CN=C(C3CCOCC3)N2N=C1OC[C@@H]1CC[C@H](CC1)C(F)(F)F
demonstrates potent antimigratory and anti-invasive effects in vitro
CAS Number: 923359-38-0
Mäkinen P
Oclacitinib - CAS# 1208319-26-9 Catalog No.:M9848-2 Smiles: CN1C(=O)C2=CN=C(C3CCOCC3)N2N=C1OC[C@@H]1CC[C@H](CC1)C(F)(F)FOclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 's) ranging from 10 to 99 nM and did not inhibit a panel of 38 non JAK kinases (IC50 's > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1 dependent cytokines involved in allergy and
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