NB-360 Size:Contact [email protected] for quotation N[C@@H](CCCCNCC(=O)C1=CC=CO1)C(O)=O

N[C@@H](CCCCNCC(=O)C1=CC=CO1)C(O)=O

InChi: InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7

In competitive experiments using membranes prepared from Chinese hamster ovary cells expressing the bradykinin receptor subtypes

VTP-27999 also blocks renin's ability to activate extracellular signal-regulated kinase 1/2 phosphorylation

NB-360 Size:Contact [email protected] for quotation N[C@@H](CCCCNCC(=O)C1=CC=CO1)C(O)=ONB 360 is a potent, brain penetrable, and orally bioavailable dual BACE1 BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB 360 shows a superior pharmacological profile and robust reduction of amyloid and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB 360 can completely block the progression of A deposition in the brains of APP transgenic mice. NB 360 shows excellent selectivity over the related aspartyl