ML277 - CAS# 1401242-74-7 etarrestin (ML246) and the combination of (Z)-SMI-4a

and the combination of (Z)-SMI-4a and a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor was highly synergistic in killing pre-T-LBL cells

7-dimethoxy-4-quinazolinyl)amino]phenol

for 4 weeks) treatment results in a more sustained pharmacodynamic inhibition of proteasome activity in tumors relative to normal tissues

parainfluenza type 5 and rhinovirus type 14

ML277 - CAS# 1401242-74-7 etarrestin (ML246) and the combination of (Z)-SMI-4aML277, CAS No. 1401242 74 7, is a potent activator of KCNQ1 (Kv7. 1) channels with >100 fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 M. KCNQ1 is a voltage gated potassium channel required for repolarization phase of the cardiac action potential. ML277 is the first selective and potent activator found, with an EC50 of 260 nM. Product information CAS Number: 1401242 74 7 Molecular Weight: 471. 59