Temozolomide Size:Solid 10 mg 7 cells at the transcriptional

7 cells at the transcriptional level

InChiKey: JZZFDCXSFTVOJY-UHFFFAOYSA-N

Montine TJ

A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis

Temozolomide Size:Solid 10 mg 7 cells at the transcriptionalTemozolomide, also known as SCH 52365 , MB39831, and RP46161, is a triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike