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Smiles: CC1=CC(=NN1CC1C=C(N=CC=1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1C=CC(=CC=1)OC(F)(F)F
and metabolism
As with recombinant cell systems
HSP90 or the 53 kinases tested
Canertinib HCl - CAS# 289499-45-2 60273 Smiles: CC1=CC(=NN1CC1C=C(N=CC=1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1C=CC(=CC=1)OC(F)(F)FCanertinib, also known as CI1033 and PD183805, CAS No. 289499 45 2, is a potent ErbB inhibitor for the treatment of cancer. It is an irreversible tyrosine kinase inhibitor with activity against EGFR (IC50 0. 8 nM), HER 2 (IC50 19 nM) and ErbB 4 (IC50 7 nM). By 2015, Pfizer had discontinued development of the drug. Canertinib has been reported as a substrate for OATP1B3. Interaction of canertinib with OATP1B3 may alter its hepatic disposition and can