Methapyrilene hydrochloride 669CT245232 is a covalent protein arginine

is a covalent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50

Chemical Name: (1S)-1-(hydroxymethyl)-3-(5

Smiles: CC(=O)O[C@@H]1CC=C(C[C@@H](OC(=O)/C(/C)=C/CO)[C@@H]2[C@@H](C=C1C)OC(=O)C2=C)CO |c:6

This yields a pA2 of around 7

Methapyrilene hydrochloride 669CT245232 is a covalent protein arginineMethapyrilene (Thenylpyramine) hydrochloride is an orally active H1 receptor antihistamine and an anticholinergic agent of the pyridine chemical class. Methapyrilene hydrochloride has hepatotoxicity and can be used as a hepatotoxin that cause periportal hepatic necrosis in vivo Product information CAS Number: 135 23 9 Molecular Weight: 297. 85 Formula: C14H20ClN3S Chemical Name: N [2 (dimethylamino)ethyl] N [(thiophen 2 yl)methyl]pyridin 2 amine