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(S)-CVN424 is a potent G-Protein-Coupled Receptor 6 (GPR6) modulator
This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines
It exhibits a variety of biological activities
In syngeneic 129S1 mice
AES-350 - CAS# 847249-57-4 12841 (S)-CVN424 is a potent G-Protein-CoupledAES 350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0. 0244 M and 0. 035 M, respectively. AES 350 is also against HDAC 3, 8, and 11 in an enzymatic activity assay with IC50 values of 0. 187 M, 0. 245 M, and >1M, respectively. AES 350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research. Product information CAS Number: 847249 57 4 Molecular Weight: 312. 36 Formula:
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