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selective and orally bioavailable inhibitor of USP7 with IC50 of 1
decreases platelet aggregation
2017 May 9
Targeting Autophagy Addiction in Cancer
A-443654 Catalog No.:M10783-2 selective and orally bioavailable inhibitorA 443654 is a potent and selective AKT inhibitor. A 443654 induces rapid Akt Ser 473 phosphorylation independent of mTORC1 inhibition. A 443654 interferes with mitotic progression by regulating aurora a kinase expression. Product information CAS Number: 552325 16 3 Molecular Weight: 397. 47 Formula: C24H23N5O Chemical Name: (2S) 1 (1H indol 3 yl) 3 {[5 (3 methyl 2H indazol 5 yl)pyridin 3 yl]oxy}propan 2 amine Smiles: