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4(12):e8104
ALK4 and ALK7) with potential anticancer activity
InChiKey: UEMQPCYDWCSVCU-UHFFFAOYSA-N
Transpl Immunol
BLU-9931 - CAS# 1538604-68-0 255 4(12):e8104BLU 9931, CAS No. 1538604 68 0, is a potent and irreversible small molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU 9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU 9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor