Trametinib DMSO solvate - CAS# 1187431-43-1 Catalog No.:M10955-10 HG-6-64-1 is a selective B-Raf

HG-6-64-1 is a selective B-Raf and mutant B-Raf inhibitor

Wnt inhibitor

1) and 5-HT-evoked increases in intracellular calcium (pIC50 = 10

CAS Number: 29608-49-9

Trametinib DMSO solvate - CAS# 1187431-43-1 Catalog No.:M10955-10 HG-6-64-1 is a selective B-RafTrametinib, also known as GSK1120212, is a n orally bioavailable inhibitor of mitogen activated protein kinase kinase (MEK MAPK ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine tyrosine kinases often upregulated in various cancer cell