AZD3759 - CAS# 1626387-80-1 Catalog No.:M6469-10 HLY78 was used at 10-20

HLY78 was used at 10-20 µM final concentration in various in vitro assays

is an acyl-sulfonamide with potential antineoplastic activity

In cells pre-treated with MBX-2982 (1 µM) in “chronic incubation/washout” experiments

is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor with an IC50 ~0

AZD3759 - CAS# 1626387-80-1 Catalog No.:M6469-10 HLY78 was used at 10-20AZD3759, CAS No. 1626387 80 1, is also known as zorifertinib. It is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR overexpressing cells. EGFR,